Rucaparib (AG-014699): Potent PARP1 Inhibitor for DNA Dam...

2026-01-20

Rucaparib (AG-014699, PF-01367338) is a highly potent PARP1 inhibitor essential for DNA damage response and cancer biology research. Its unique selectivity, radiosensitization effect in PTEN-deficient and ETS fusion-expressing cancer cells, and defined physicochemical parameters make it a benchmark tool for investigating DNA repair pathways.